Contract manufacturing

In the field of contract manufacturing, we focus on production of nutritional supplements, pharmaceuticals, acknowledged curative preparations and technological processing of active and auxiliary substances. Applied production technologies and pharmaceutical forms produced at present in our company are as follows:

SOLID PHARMACEUTICAL FORM

1. Tablets, powdery products, granulates, microtablets, 2-layer tablets and combinations (COMBICAPS)

1.1. Methods of granulate preparation
- humid granulation,
- dry granulation,
- blending (direct compacting)

1.2. Tablets

TABLET FORMATS
Type Size of the tablet
Score line
Height (mm) Weight (mg) Suitable blister (code) - depends
on the height of the tablet
New release! Microtablets
a) Standard microtablets
b) 2-layer microtablets
Ø 2 mm no 2 5-7 filled into capsules
biconvex lens  Ø 5,5 mm no 3 - 4 80 - 110 not available
biconvex lens  Ø 8 mm possible 2,5 - 6 200 - 400 10/8
biconvex lens Ø 9 mm possible 2,5 - 7 250 - 450 30/9a,b; 15/9
biconvex lens Ø 12 mm possible 3,5 - 7 300 - 600 10/12a,b
biconvex lens Ø 20 mm possible 2,5 - 5 1000 - 2000 6/20a,b
oblong 19x8 possible 3,5 - 8 800 - 1700 10/19; 10/0; 12/0; 20/0; 15/19
oval 18x8,5 possible 3,5 - 8 800 - 1700 10/19; 15/19
oval 19x9 possible 3,5 - 8 800 - 1700 10/19; 15/19
oval 20x7 no 3,5 - 8 800 - 1400 10/0; 12/0; 20/0
oval 15x8 no 4,0 - 7 400 - 800 15/15
2layer oval 15x8 no 4,0 - 7 400 - 800 15/15


1.3 Film coating of tablets (Aquacoat, Opadry, Sepifilm and Easycoat)

2. Capsules - gelatine (HGC), vegetarian (HPMC), pullulan, delayed release (DR)

Capsule formats
Size
Weight (mg) Capacity (mg) - depends
on powder density
Closed length (mm) Suitable blister (code)
New release!
00  
118±7 550 - 1090 23,3±0,3 10/00; 12/00
0   96±6 400 - 800 21,7±0,3 10/0; 12/0; 20/0
1   76±5 300-600 19,4±0,3  
3   48±3 180 - 350 15,9±0,3 10/3


3. New release! COMBICAPS / ! Hard capsules filled with oil, combination of oils or combination of oil+other forms (pellets, granulates or microtablets)
FIRST-RATE REPLACEMENT OF SOFT GELATIN CAPSULES

- we fill hard gelatine capsules (HGC), vegetarian capsules (HPMC), delayed release capsules (DR) and others
- capsules are locked (stripped) by strip band to ensure 100% tightness
- capsules size 0 can be filled with oils and combinations of oils and other materials (pellets, granulates, microtablets)

Type Filling no.1 Filling no.2
OIL oil x
OIL-OIL oil oil
OIL-MICROTABLETS oil microtablets
OIL-PELLETS oil pellets

HALF-LIQUID PHARMACEUTICAL FORM

- production of pastes, ointments, creams and reverse emulsions

LIQUID PHARMACEUTICAL FORM

- production of solutions, suspensions and sprays

PACKAGING OF SOLID, HALF-LIQUID AND LIQUID FORMS

Packaging of solid forms includes:
- filling and packing into glass or plastic phials
- filling into sachets and sticks
- packing into PVC / Alu blisters
- packing of blisters, phials and tubes into boxes

Alu blisters formats
Code
Size (mm) No.of tbl/cps in blister Suitable type of tbl/cps Maximal height of the tablet
10/00 New release! 115x63 10 cps size 00 -
12/00 New release! 115x63 12 cps size 00 -
30/9a  115x63 30 tbl Ø 9 mm 4,2 mm
30/9b 115x63 30 tbl Ø 9 mm 3,4 mm
15/19 115x63 15 oval 19x9 mm 8,1 mm
15/15 115x62 15 tbl 2layer 15x8 mm 6 mm
6/20a 60x87 6 tbl Ø 20 mm 4,5 mm
6/20b 60x87 6 tbl Ø 20 mm 3 mm
10/19 62x77 10 tbl 19x8 mm 8 mm
10/3 62x77 10 cps size 3  
10/0 62x77 10 cps size 0 OR tbl 20x7 mm 8 mm
12/0 72x97 12 cps size 0 OR tbl 20x7 mm 8 mm
20/0 68x124 20 cps size 0 OR tbl 20x7 mm 8 mm
10/12a 97x40 10 tbl Ø 12 mm 6,6 mm
10/12b 97x40 10 tbl Ø 12 mm 4,9 mm
15/9 78x48 15 tbl Ø 9 mm 4,2 mm
10/8 42x98 10 tbl Ø 8 mm 3,7 mm

Packaging of half-liquid forms includes:
- filling and packing into tubes, dispensers and glass, plastic or metal phials
tubes ormats (Tube diameter - Ø 18, mm, tbl Ø 25 mm, tbl Ø 30 mm, tbl Ø 35 mm, tbl Ø 50 mm, )

Packaging of liquid forms includes:
- filling and packing into flaskets, dispensers and glass, plastic or metal phials

TECHNOLOGICAL PROCESSING OF ACTIVE AND AUXILIARY SUBSTANCES

- Decreasing the particle dimensions (micronization)
- Increasing the particle dimensions
- Modified release
- One-layer tablets
- Two-layer tablets
- Coating
- Sealing of capsules (tamper evident)
- Filling of hard capsules with oils, granulates, powders, pellets, icrotablets and combinations (COMBICAPS)
- Blistering
- Pellet preparation and production