Manufacturing
Contract manufacturing
In the field of contract manufacturing, we focus on production of nutritional supplements, pharmaceuticals, acknowledged curative preparations and technological processing of active and auxiliary substances. Applied production technologies and pharmaceutical forms produced at present in our company are as follows:
SOLID PHARMACEUTICAL FORM
1. Tablets, powdery products and granulates
1.1. Methods of granulate preparation
- humid granulation,
-
dry granulation,
-
blending (direct compacting)
1.2. Tablets
Tablet formats
| Type | Size of the tablet |
Score line |
Height (mm) | Weight (mg) | Suitable blister (code) - depends on the height of the tablet |
|---|---|---|---|---|---|
| biconvex lens | Ø 8 mm | possible | 2,5 - 6 | 200 - 400 | 10/8 |
| biconvex lens | Ø 9 mm | possible | 2,5 - 7 | 250 - 450 | 30/9a,b; 15/9 |
| biconvex lens | Ø 12 mm | possible | 3,5 - 7 | 300 - 600 | 10/12a,b |
| biconvex lens | Ø 20 mm | possible | 2,5 - 5 | 1000 - 2000 | 6/20a,b |
| oblong | 19x8 | yes | 3,5 - 8 | 800 - 1700 | 10/19; 10/0; 12/0; 20/0; 15/19 |
| oval | 18x8,5 | possible | 3,5 - 8 | 800 - 1700 | 10/19; 15/19 |
| oval | 19x9 | possible | 3,5 - 8 | 800 - 1700 | 10/19; 15/19 |
| oval | 20x7 | no | 3,5 - 8 | 800 - 1400 | 10/0; 12/0; 20/0 |
| oval | 15x8 | no | 4,0 - 7 | 400 - 800 | 15/15 |
| 2layer oval | 15x8 | no | 4,0 - 7 | 400 - 800 | 15/15 |
1.3 Film coating of tablets (Aquacoat, Opadry, Sepifilm and Easycoat)
2. Capsules
Capsule formats
| Size |
Weight (mg) | Capacity (mg) - depends on powder density |
Closed length (mm) | Suitable blister (code) |
|---|---|---|---|---|
| 0 | 96±6 | 400 - 800 | 21,7±0,3 | 10/0; 12/0; 20/0 |
| 3 | 48±3 | 180 - 350 | 15,9±0,3 | 10/3 |
HALF-LIQUID PHARMACEUTICAL FORM
- production of pastes, ointments, creams and reverse emulsions
LIQUID PHARMACEUTICAL FORM
- production of solutions, suspensions and sprays
PACKAGING OF SOLID, HALF-LIQUID AND LIQUID FORMS
Packaging of solid forms includes:
- packing into PVC / Alu blisters,
Alu blisters formats
| Code |
Size (mm) | No.of tbl/cps in blister | Suitable type of tbl/cps | Maximal height of the tablet |
|---|---|---|---|---|
| 30/9a | 115x63 | 30 | tbl Ø 9 mm | 4,2 mm |
| 30/9b | 115x63 | 30 | tbl Ø 9 mm | 3,4 mm |
| 15/19 | 115x63 | 15 | oval 19x9 mm | 8,1 mm |
| 15/15 | 115x62 | 15 | tbl 2layer 15x8 mm | 6 mm |
| 6/20a | 60x87 | 6 | tbl Ø 20 mm | 4,5 mm |
| 6/20b | 60x87 | 6 | tbl Ø 20 mm | 3 mm |
| 10/19 | 62x77 | 10 | tbl 19x8 mm | 8 mm |
| 10/3 | 62x77 | 10 | cps size 3 | |
| 10/0 | 62x77 | 10 | cps size 0 tbl 20x7 mm | 8 mm |
| 12/0 | 72x97 | 12 | cps size 0 tbl 20x7 mm | 8 mm |
| 20/0 | 68x124 | 20 | cps size 0 tbl 20x7 mm | 8 mm |
| 10/12a | 97x40 | 10 | tbl Ø 12 mm | 6,6 mm |
| 10/12b | 97x40 | 10 | tbl Ø 12 mm | 4,9 mm |
| 15/9 | 78x48 | 15 | tbl Ø 9 mm | 4,2 mm |
| 10/8 | 42x98 | 10 | tbl Ø 8 mm | 3,7 mm |
- filling and packing into glass or plastic flaskets
- filling into sacks and sticks
Packaging of half-liquid forms includes:
- filling and packing into tubes, dispensers and glass, plastic or metal phials
tubes ormats (Tube diameter -
tbl Ø 25 mm, tbl Ø 30 mm, tbl Ø 35 mm, tbl Ø 50 mm, )
Packaging of liquid forms includes:
- filling and packing into flaskets, dispensers and glass, plastic or metal phials
TECHNOLOGICAL PROCESSING OF ACTIVE AND AUXILIARY SUBSTANCES
- Decreasing the particle dimensions, Increasing the particle dimensions, One-layer tablets, Two-layer tablets, Coating,
Blistering, Pellet preparation and production
